Clomid is definitely a mouth medication that can be used to trigger ovulation. It works by stopping estrogen receptors at the hypothalamus, and that is an important "hormonal controls center" for the body. When this happens, the hypothalamus is stimulated to launch follicle stimulating hormone (FSH), and luteinizing hormone (LH). These are the obviously developing ovarian stimulants, which prompt ovulation in a normal cycle.